Simak Ali Selected Research

pyrimidine

12/2010

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.

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Simak Ali Research Topics

Disease

46	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2002
33	Neoplasms (Cancer) 01/2022 - 12/2003
5	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2012
3	Prostatic Neoplasms (Prostate Cancer) 02/2014 - 09/2004
3	Hypersensitivity (Allergy) 07/2005 - 08/2002
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 01/2016
2	Circulating Neoplastic Cells 01/2017 - 07/2015
1	Infections 01/2022
1	Disease Progression 12/2021
1	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2021
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2018
1	Carcinoma (Carcinomatosis) 06/2017
1	Retinal Diseases 01/2017
1	Vascular System Injuries 01/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2015
1	Triple Negative Breast Neoplasms 08/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2011

Drug/Important Bio-Agent (IBA)

13	Estrogen ReceptorsIBA 01/2022 - 08/2003
10	Estrogen Receptor alphaIBA 01/2022 - 08/2002
10	Tamoxifen FDA LinkGeneric 11/2020 - 12/2003
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2002
8	Pharmaceutical PreparationsIBA 01/2020 - 12/2008
8	Estrogens (Estrogen)FDA Link 01/2012 - 08/2003
6	Transcription Factors (Transcription Factor)IBA 01/2018 - 09/2004
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2016
5	Aromatase InhibitorsIBA 01/2017 - 12/2003
5	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2017 - 08/2002
3	LigandsIBA 01/2022 - 12/2003
3	Cell-Free Nucleic AcidsIBA 01/2021 - 07/2015
3	Hormones (Hormone)IBA 01/2021 - 01/2018
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2013
3	Androgen Receptors (Androgen Receptor)IBA 09/2016 - 09/2004
3	ChromatinIBA 01/2016 - 01/2012
2	Circulating Tumor DNAIBA 01/2021 - 01/2019
2	Cytosine DeaminaseIBA 01/2021 - 11/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2018 - 06/2017
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2017 - 12/2010
2	Phenobarbital (Luminal)FDA Link 04/2015 - 12/2008
2	Biological ProductsIBA 04/2015 - 04/2015
2	AndrogensIBA 12/2013 - 09/2004
1	Matrix Metalloproteinases (MMPs)IBA 01/2022
1	Single-Stranded DNA (DNA, Single Stranded)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	ribociclibIBA 12/2021
1	MicroRNAs (MicroRNA)IBA 10/2021
1	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020
1	EndonucleasesIBA 01/2020
1	UracilIBA 01/2020
1	Retinoid X Receptor gammaIBA 10/2019
1	exemestane (Aromasin)FDA Link 05/2019
1	APOBEC-1 DeaminaseIBA 11/2017
1	Peptides (Polypeptides)IBA 11/2017
1	Small Interfering RNA (siRNA)IBA 06/2017
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2017
1	Selective Estrogen Receptor Modulators (SERM)IBA 01/2017
1	Epithelial Cell Adhesion MoleculeIBA 01/2017
1	Messenger RNA (mRNA)IBA 12/2016
1	OF 900IBA 12/2016
1	Cyclin HIBA 12/2016
1	Orphan Nuclear ReceptorsIBA 01/2016
1	Serine (L-Serine)FDA Link 01/2016
1	TabletsIBA 01/2016
1	IronIBA 01/2016
1	Transferrin (beta 2 Transferrin)IBA 01/2016
1	CytidineIBA 10/2015
1	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 07/2015
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 07/2015
1	PPAR gammaIBA 04/2015
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 04/2015
1	Phosphotransferases (Kinase)IBA 06/2014
1	CollagenIBA 06/2014
1	Fibronectins (Fibronectin)IBA 06/2014
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 06/2014
1	IntegrinsIBA 06/2014
1	Glycine N-Methyltransferase (Glycine Sarcosine N-Methyltransferase)IBA 12/2013
1	S-Adenosylmethionine (Ademetionine)IBA 12/2013
1	MethyltransferasesIBA 12/2013
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2011
1	pyrimidineIBA 12/2010
1	Antineoplastic Agents (Antineoplastics)IBA 08/2009
1	BS-181IBA 08/2009
1	Cell Surface ReceptorsIBA 10/2007
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 10/2007
1	AntibodiesIBA 10/2007
1	SteroidsIBA 07/2005
1	Estradiol (Delestrogen)FDA LinkGeneric 07/2005
1	Tyrosine Kinase InhibitorsIBA 06/2005
1	Anastrozole (Arimidex)FDA LinkGeneric 06/2005
1	Gefitinib (Iressa)FDA Link 06/2005
1	ErbB Receptors (EGF Receptor)IBA 06/2005
1	Histone Deacetylase 1IBA 02/2005
1	theasinensin AIBA 12/2004
1	Histone Deacetylase InhibitorsIBA 12/2004
1	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 12/2004
1	Cyclin D1IBA 12/2004
1	trichostatin A (A 300)IBA 12/2004

Therapy/Procedure

24	Therapeutics 12/2021 - 12/2003
4	Drug Therapy (Chemotherapy) 12/2021 - 01/2021
1	Oral Administration 12/2010